How Does Complement Affect Hematological Malignancies: From Basic Mechanisms to Clinical Application

Targeted Therapy in Hematological Malignancies: From Basic Research to Clinical Practice

1Department of Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China 2Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin, China 4Department of Translational Molecular Pathology, The Universit...

MicroRNAs: from basic mechanisms to clinical application in cardiovascular medicine.

How Does Monetary Policy Affect Household Income Distribution?

Over the last decades the research on monetary policy has largely concentrated on the impact of monetary authorities’ decisions on inflation and the fine-tuning of the macroeconomic, so that distributional effects of monetary policy which are non-trivial has been ignored. A view that has become increasingly popular since the financial crisis 2008 is that expansionary monetary policy can exacerb...

Trichothiodystrophy: from basic mechanisms to clinical implications.

Trichothiodystrophy (TTD) is an autosomal recessive disorder with symptoms affecting several tissues and organs. The most relevant features are hair abnormalities, physical and mental retardation, ichthyosis, signs of premature aging and cutaneous photosensitivity. The clinical spectrum of TTD varies widely from patients with only brittle, fragile hair to patients with the most severe neuroecto...

Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies.

Although glucocorticoids (GCs) have been used for their immunosuppressive, anti-inflammatory, and cytotoxic effects for many years, their precise mechanism of action has not been fully elucidated. Evidence indicates that GCs induce apoptosis in hematological cells, thus supporting their use as chemotherapeutic agents for leukemias, lymphomas, and myeloma. Although much research has been focused...